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Anti-HSP27 Hspb1 Monoclonal Antibody

Boster Bio Anti-HSP27 Hspb1 Monoclonal Antibody catalog # MA1048. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rabbit, Rat.

Product Specifications

Background

The heat-shock proteins (HSPs) belong to a larger group of polypeptides, the stress proteins, that are induced in various combinations in response to environmental challenges and developmental transitions. Heat-shock 27-kD protein1also knows as HSPB. Synthesis of the small (27-kD) HSP has been shown to be correlated with the acquisition of thermotolerance. HSP27 gene is mapped to 7q11.23. Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.

Synonyms

Heat shock protein beta-1; HspB1; Heat shock 27 kDa protein; HSP 27; Hspb1; Hsp27

Gene Name

Heat shock protein beta-1

UniProt

P42930

Host

Mouse

Reactivity

Human, Mouse, Rabbit, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Partially purified inhibitor of actin polymerization (IAP) protein from turkey gizzard smooth muscle.

Clonality

Monoclonal

Clone

Clone: IAP-9

Tissue Specificity

Expressed in a variety of tissues. High levels in lung, adrenal, xiphoid, adipose tissue, heart and striated and smooth muscle, lower levels in the CNS. Adult levels are much higher in the slow-twitch soleus muscle than in the fast-twitch rectus femoris and extensor digitorum muscles. .

Applications

IHC, ICC, WB

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Chaperones, Contractility, Heat Shock Proteins, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Involved in stress resistance and actin organization.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=MA1048

Product MSDS

https://www.bosterbio.com/msds?sku=MA1048

Fragment

Mouse IgG1

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 1-2μg/ml, Human, mouse, rabbit, rat, By Heat <br>Immunocytochemistry , 1μg/ml, Human, mouse, rabbit, rat, -<br>Immunohistochemistry (Frozen Section), 1-2μg/ml, Human, mouse, rabbit, rat, -<br>Western blot, 0.5-2μg/ml, Human, mouse, rabbit, rat<br>

Other Gene Names

HSPB1

Subcellular Location

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (By similarity) . .

Sequence Similarities

Belongs to the small heat shock protein (HSP20) family.

Protein Name

Heat shock protein beta-1

Curated Selection

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