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Anti-Collagen, Type III Col3a1 Antibody (Monoclonal, FH-7A)

Anti-Collagen

Product Specifications

Background

Collagen type III, also known as COL3A1, is assigned to chromosome 2. Ultrastructural analysis of tissues from mutant mice revealed that type III collagen is essential for normal collagen I fibrillogenesis in the cardiovascular system and other organs. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development.

Synonyms

Collagen alpha-1 (III) chain; Col3a1

Gene Name

Collagen alpha-1 (III) chain

UniProt

P13941

Host

Mouse

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Human collagen type III.

Clonality

Monoclonal

Clone

Clone: FH-7A

Tissue Specificity

Expressed on the plasma membrane of hepatocytes and in the narrow apical portions of supporting cells in the vomeronasal sensory epithelium. Detected in the type III alveolar cells of the lung, in the proliferative crypt epithelium of the small intestine and in the older intragemmal cells of the tongue. .

Applications

IHC, WB

Field of Research

Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Mesenchymal Stem Cells, Signal Transduction, Stem Cells

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity) . .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=MA1029

Product MSDS

https://www.bosterbio.com/msds?sku=MA1029

Fragment

Mouse IgG1

Applications Notes

Immunohistochemistry (Frozen Section), 0.5-1μg/ml, Human, rat, -<br>Western blot, 0.25-0.5μg/ml, Human, rat<br>

Other Gene Names

COL3A1

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Sequence Similarities

Belongs to the fibrillar collagen family.

Protein Name

Collagen alpha-1 (III) chain

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