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Anti-Cathepsin L Ctsl Antibody (Monoclonal, 33/2)

Boster Bio Anti-Cathepsin L Ctsl Antibody (Monoclonal, 33/2) catalog # MA1014. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Cathepsin L is a lysosomal cysteine proteinase with a major role in intracellular protein catabolism. It also shows the most potent collagenolytic and elastinolytic activity in vitro of any of the cathepsins. Cathepsin L has been implicated in pathologic processes including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Human liver cathepsin L consists of a heavy chain of about 25 kD and a light chain of about 5 kD. The gene is mapped to 9q21-q22. Cathepsin L is required for endothelial progenitor cell-induced neovascularization.

Synonyms

Cathepsin L1;3.4.22.15; Cathepsin L; Cyclic protein 2; CP-2; Major excreted protein; MEP; Procathepsin L; Cathepsin L1 heavy chain; Cathepsin L1 light chain; Ctsl; Ctsl1

Gene Name

Cathepsin L1

UniProt

P07154

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Procathepsin L isolated from the human lung cancer cell line EPLC 32M1.

Clonality

Monoclonal

Clone

Clone: 33/2

Tissue Specificity

Both mature cathepsin L1 and procathepsin L are found in the upper epidermis. The lower epidermis predominantly contains procathepsin L. In seminiferous tubules expression is greater at stages VI-VII than at stages IX-XII. .

Applications

IHC, WB

Field of Research

Cell Adhesion Proteins, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Membrane Proteins, Neuroscience, Signal Transduction

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Important for the overall degradation of proteins in lysosomes. Procathepsin L is required for maximal stimulation of steroidogenesis by TIMP1. .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=MA1014

Product MSDS

https://www.bosterbio.com/msds?sku=MA1014

Fragment

Mouse IgG1

Applications Notes

Immunohistochemistry (Frozen Section), 4μg/ml, Human, mouse, rat, -<br>Western blot, 0.1-0.5μg/ml, Human, mouse, rat<br>

Other Gene Names

CTSL1

Subcellular Location

Lysosome .

Sequence Similarities

Belongs to the peptidase C1 family.

Protein Name

Cathepsin L1

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