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Human Transthyretin/TTR ELISA Kit EZ-Set™ (DIY Antibody Pairs)

Human Transthyretin/TTR ELISA Kit EZ-Set™ (DIY Antibody Pairs) (antibody pairs and standards for assay development) . Quantitate Human TTR in cell culture supernatants, serum and plasma (heparin, EDTA) .

Product Specifications

Background

Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

Synonyms

Transthyretin; ATTR; Prealbumin; TBPA; TTR; PALB

Gene Name

Transthyretin

UniProt

P02766

Reactivity

Human

Cross Reactivity

There is no detectable cross-reactivity with other relevant proteins.

Immunogen

Expression system for standard: E.coli; Immunogen sequence: G21-E147

Tissue Specificity

Detected in serum and cerebrospinal fluid (at protein level) . Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.

Applications

ELISA

Field of Research

Alzheimer's Disease, Cardiovascular, Neurodegenerative Disease, Neurology Process, Neuroscience, Serum Proteins

Sample Type

Cell culture supernatants, serum and plasma (heparin, EDTA) .

Detection Range

312 pg/ml - 20,000 pg/ml

Function

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Storage Conditions

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EZ1684

Product MSDS

https://www.bosterbio.com/msds?sku=EZ1684

Other Gene Names

TTR

Subcellular Location

Secreted. Cytoplasm.

Curated Selection

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