SAHM1

SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice[1][2].

Product Specifications

CAS Number

[2050906-89-1]

UNSPSC

12352209

Target

Notch

Type

Peptides

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sahm1.html

Purity

96.40

Solubility

10 mM in DMSO

Smiles

C[C@@H](O)[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC1=CN=CN1)NC([C@@H](NC([C@]2(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](C)(CCC/C=C/CCC2)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC(CCNC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CS)=O)CCCNC(N)=N)=O)C)=O)CC3=CN=CN3)=O)=O)=O

Molecular Formula

C94H162N36O23S

Molecular Weight

2196.58

References & Citations

[1]Ashley JW, et, al. Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem. 2015 Nov;116 (11) :2598-609.|[2]KleinJan A, et, al. The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J Allergy Clin Immunol. 2018 Jul;142 (1) :76-85.e8.