Matrine

Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) [1][2][3][4][5].

Product Specifications

CAS Number

[519-02-8]

Product Name Alternative

Matridin-15-one; Vegard; α-Matrine

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Ferroptosis; Mitophagy; Opioid Receptor; PINK1/Parkin

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Matrine.html

Purity

98.0

Solubility

DMSO : ≥ 50 mg/mL|H2O : 20 mg/mL (ultrasonic)

Smiles

O=C1CCC[C@]2([H])[C@@]3([H])CCCN4[C@@]3([H])[C@](CCC4)([H])CN21

Molecular Formula

C15H24N2O

Molecular Weight

248.37

Precautions

H302

References & Citations

[1]Ying Zhang, et al. Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology. 2009 Apr;59 (3) :191-200. |[2]Songbo Fu, et al. Matrine induces papillary thyroid cancer cell apoptosis in vitro and suppresses tumor growth in vivo by downregulating miR-182-5p. Biomed Pharmacother. 2020 Aug;128:110327. |[3]Bei Zhao, et al. Matrine suppresses lung cancer metastasis via targeting M2-like tumour-associated-macrophages polarization. Am J Cancer Res. 2021 Sep 15;11 (9) :4308-4328. |[4]Lu Yuan, et al. Matrine alleviates cisplatin‐induced acute kidney injury by inhibiting mitochondrial dysfunction and inflammation via SIRT3/OPA1 pathway. J Cell Mol Med v.26 (13) ; 2022 Jul. |[5]Runjie Wei, et al. Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways. Cell Stress Chaperones. 2018 Nov;23 (6) :1295-1309.