E17241

E17241 is an inducer of the expression of ABCA1 that increases the protein levels of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs) . E17241 decreases plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose (HFHG) diet[1][2].

Product Specifications

CAS Number

[1060968-92-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/e17241.html

Purity

95.04

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C2SCCS2)C=C1)NC3=NC=CC=C3O

Molecular Formula

C15H14N2O2S2

Molecular Weight

318.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Sheng R, et al. A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue. Biomed Pharmacother. 2024 Mar;172:116220.|[2]Xu Y, et al. E17241 as a novel ABCA1 (ATP-binding cassette transporter A1) upregulator ameliorates atherosclerosis in mice[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41 (6) : e284-e298.