VU 0240551

VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission[1][2].

Product Specifications

CAS Number

[893990-34-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/VU-0240551.html

Purity

99.70

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(CSC1=NN=C(C2=CC=CC=C2)C=C1)NC3=NC(C)=CS3

Molecular Formula

C16H14N4OS2

Molecular Weight

342.44

Precautions

H302, H315, H319, H335

References & Citations

[2]Wang Y, et al. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Neuroscience. 2015;298:397-409.|[3]Balapattabi K, et al. Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging. J Neuroendocrinol. 2019;31 (8) :e12752.|[1]Delpire E, et al. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106 (13) :5383-8.