Ferroptosis inducer-4

Ferroptosis inducer-4 (Compound 5) is a ferroptosis (Ferroptosis) inducer with a structure featuring terminal double bonds introduced at the sn-2 position of phospholipids. Ferroptosis inducer-4 exhibits significant cytotoxicity towards HT-1080 cells, with an IC50 of 18 μM. This cytotoxic mechanism involves the generation of lipid peroxides and oxidative damage to the cell membrane triggered by the terminal double bonds. Ferroptosis inducer-4 can be used for research on ferroptosis regulation[1].

Product Specifications

CAS Number

[3055534-10-3]

UNSPSC

12352211

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ferroptosis-inducer-4.html

Smiles

C[N+](C)(C)CCOP(OC[C@H](OC(CC/C=C/C=C)=O)COCCCCCCCCCCCCCCCCCC)([O-])=O

Molecular Formula

C33H64NO7P

Molecular Weight

617.84

References & Citations

[1]Zhang Q, et al. Synthesis of Plasmalogen Derivatives with Unnatural Fatty Acids as Substrates for Ferroptosis Induction. ACS Chem Biol. 2024 Aug 8.