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Amyloid Beta 1-42 Oligomer Antibody: HRP

Rabbit Anti-Human Amyloid Beta 1-42 Oligomer Recombinant Monoclonal IgG

Product Specifications

Background

Our amyloid beta oligomer antibody (clone 1C1) has been tested for specificity against synthetic AB 1-42 aggregates, with higher specificity to oligomers demonstrated. In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (1). The immunogen used was our Amyloid Beta 1-42 (Aβ42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published (2,3).

Specifications

Amyloid Beta 1-42 oligomers

Product Name Alternative

Abeta Oligomers Antibody, APP Antibody

Synonyms

Amyloid Beta 1-42 Oligomer Antibody, Clone 1C1: HRP

UNSPSC

12352203

Gene ID

351 (APP)

Swiss Prot

P05067

Cellular Locus

Membrane (Secreted)

Host

Rabbit

Species Reactivity

Human

Immunogen

Amyloid beta 1-42 oligomers (StressMarq Catalog# SPR-488)

Target

Amyloid Beta 1-42 Oligomer

Clonality

Recombinant

Isotype

IgG

Clone

1C1

Conjugation

HRP

Tissue Specificity

CNS, Blood

Validated Applications

WB,IHC,ELISA

Purification

Protein A Purified

Limit Of Detection

A 1:10,000 dilution of SMC-619 was sufficient for detection of 1ug of AB 1-42 oligomers by western blot analysis with goat-anti-rabbit:HRP as the secondary and by self-sandwich ELISA analysis (capture at 1 ug/mL, detection at 0.2 ug/mL).

Concentration

0.5 mg/ml

Dilution

WB, ELISA (1:1000 - 1:10,000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Panza et al. 2019. Nat Rev Neurol. 15:73-88 https://doi.org/10.1038/s41582-018-0116-6 2. Stine et al. 2003. JBC. 278(13):11612-22. doi: 10.1074/jbc.M210207200 3. Ahmed et al. 2010. Nature Structural & Molecular Biology. 17(5):561 doi: 10.1038/nsmb.1799

Product Datasheet

https://cdn.gentaur.com/products/400/5467731981148/datasheet/smc-619d-hrp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/5467731981148/msds/smc-619d-hrp.pdf

CAS Number

9007-83-4

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