CCR4 antagonist 4
CCR4 antagonist 4 (compound 22) is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50 of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC50: 0.007 μM) and Ca2+ mobilization (IC50: 0.003 μM) . CCR4 antagonist 4 can be used for allergic inflammation research[1].
Product Specifications
CAS Number
[668980-17-4]
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ccr4-antagonist-4.html
Purity
99.72
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC(C=C(C=C1)Cl)=C1CNC2=NC(N3CCN(CC3)C([C@H]4CCCCN4)=O)=NC5=C2C=CC=N5
Molecular Formula
C24H27Cl2N7O
Molecular Weight
500.42
References & Citations
[1]Purandare AV, et al. Core exploration in optimization of chemokine receptor CCR4 antagonists. Bioorg Med Chem Lett. 2007 Feb 1;17 (3) :679-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR4
Available Sizes
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