MW-150

MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].

Product Specifications

CAS Number

[1628502-91-9]

Product Name Alternative

MW01-18-150SRM

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335

Target

Autophagy; p38 MAPK

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mw-150.html

Purity

99.89

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1

Molecular Formula

C24H23N5

Molecular Weight

381.47

Precautions

H315, H317, H319, H335

References & Citations

[1]Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6 (4) :666-80.