Salusin-β

Salusin-β is an endogenous bioactive peptide with significant hemodynamic and mitogenic activity. Salusin-β can stimulate the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, leading to a rapid and significant decrease in blood pressure and heart rate. In addition, Salusin-β can stimulate the release of arginine vasopressin from the pituitary gland in rats. This makes Salusin-β have important application potential in cardiovascular disease research[1].

Product Specifications

CAS Number

[624735-23-5]

UNSPSC

12352209

Target

Endogenous Metabolite

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/salusin-β.html

Smiles

C[C@H](N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N3[C@@H](CCC3)C(N4[C@@H](CCC4)C(O)=O)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C115H176N32O21

Molecular Weight

2342.83

References & Citations

[1]Shichiri, et al. "Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities." Nature medicine 9.9 (2003) : 1166-1172.