Glicoricone

Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC50 of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity[1][2].

Product Specifications

CAS Number

[161099-37-2]

UNSPSC

12352005

Target

Estrogen Receptor/ERR; Monoamine Oxidase

Type

Natural Products

Related Pathways

Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glicoricone.html

Purity

96.0

Solubility

10 mM in DMSO

Smiles

O=C1C(C2=C(O)C=C(O)C(C/C=C(C)\C)=C2OC)=COC3=CC(O)=CC=C13

Molecular Formula

C21H20O6

Molecular Weight

368.38

References & Citations

[1]Hatano T, et, al. Phenolic constituents of licorice. III. Structures of glicoricone and licofuranone, and inhibitory effects of licorice constituents on monoamine oxidase. Chem Pharm Bull (Tokyo) . 1991 May;39 (5) :1238-43.|[2]Boonmuen N, et, al. Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities. Steroids. 2016 Jan;105:42-9.