DBCO-NHS ester

DBCO-NHS ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[1353016-71-3]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-nhs-ester.html

Purity

99.54

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(CCC(ON(C(CC1)=O)C1=O)=O)N(C(C=CC=C2)=C2C#C3)CC4=C3C=CC=C4

Molecular Formula

C23H18N2O5

Molecular Weight

402.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Method for identifying potential drug target protein useful for development of antibody drug, and method for producing antibody directed against target protein. WO2018151301A1.