Shield-1

Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD) [1][2][3].

Product Specifications

CAS Number

[914805-33-7]

Product Name Alternative

Shld1

UNSPSC

12352005

Target

FKBP

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/shield-1.html

Purity

99.73

Solubility

DMSO : 67.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5

Molecular Formula

C42H56N2O10

Molecular Weight

748.90

References & Citations

[1]Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296 (1) :F204-11.|[2]Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17 (1) :763-770.|[3]Laura A Banaszynski, et al. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell. 2006 Sep 8;126 (5) :995-1004.