Fluoroclebopride

Fluoroclebopride binds reversibly to dopamine receptors. 18F labeled fluoroclebopride has been used as a probe for studying D2/D3 receptor availability via PET in various monkey models[1][2].

Product Specifications

CAS Number

[154540-49-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fluoroclebopride.html

Purity

99.90

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C(NC1CCN(CC2=CC=C(F)C=C2)CC1)C3=CC(Cl)=C(N)C=C3OC

Molecular Formula

C20H23ClFN3O2

Molecular Weight

391.87

Precautions

H315, H319, H320

References & Citations

[1]Nader MA, Czoty PW. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry. 2005 Aug;162 (8) :1473-82. |[2]Czoty PW, et al. Effects of repeated treatment with the dopamine D2/D3 receptor partial agonist aripiprazole on striatal D2/D3 receptor availability in monkeys. Psychopharmacology (Berl) . 2013 Sep 29:10.1007/s00213-013-3274-7.