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COX-2-IN-43

COX-2-IN-43 (Compound MYM4) is a COX-2 inhibitor (IC50: 0.983 and 0.247 μM for COX-1 and COX-2 respectively) . COX-2-IN-43 inhibits cancer cell proliferation and colonization, induces apoptosis[1].

Product Specifications

CAS Number

[1023524-40-4]

UNSPSC

12352005

Target

Apoptosis; COX

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cox-2-in-43.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C(NC2=CC=C(C=C2)OC(F)(F)F)=O)C(C3=C(C=CC=C3Cl)Cl)=NO1

Molecular Formula

C18H11Cl2F3N2O3

Molecular Weight

431.19

References & Citations

[1]Hawash M, et al. Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling. Eur J Med Chem. 2024 Apr 15;271:116397.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-1; COX-2

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