COX-2-IN-43
COX-2-IN-43 (Compound MYM4) is a COX-2 inhibitor (IC50: 0.983 and 0.247 μM for COX-1 and COX-2 respectively) . COX-2-IN-43 inhibits cancer cell proliferation and colonization, induces apoptosis[1].
Product Specifications
CAS Number
[1023524-40-4]
UNSPSC
12352005
Target
Apoptosis; COX
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cox-2-in-43.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(NC2=CC=C(C=C2)OC(F)(F)F)=O)C(C3=C(C=CC=C3Cl)Cl)=NO1
Molecular Formula
C18H11Cl2F3N2O3
Molecular Weight
431.19
References & Citations
[1]Hawash M, et al. Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling. Eur J Med Chem. 2024 Apr 15;271:116397.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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