SIBA

SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies[1][2][3].

Product Specifications

CAS Number

[35899-54-8]

Product Name Alternative

5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HSV; Nucleoside Antimetabolite/Analog; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/SIBA.html

Purity

99.64

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3CSCC(C)C

Molecular Formula

C14H21N5O3S

Molecular Weight

339.41

Precautions

H302, H315, H319, H335

References & Citations

[1]F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6 (1) :3-16.|[2]B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine. J Virol. 1977 Apr;22 (1) :160-7.|[3]Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204 (3) :853-9.