BMVC4
Product Specifications
UNSPSC Description
BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3(T2AG3)3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/bmvc4.html
Smiles
C[N+]1=CC(/C=C/C2=CC3=C(NC4=C3C=C(/C=C/C5=NC=C[N+](C)=C5)C=C4)C=C2)=NC=C1.[I-].[I-]
Molecular Weight
659.30
References & Citations
[1]A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111297/BMVC4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111297/
Clinical Information
No Development Reported
CAS Number
868843-84-9
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
CSB-EP844722HU-01 20 µg
Recombinant Human Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1)
Ask
View Details CSB-EP844722HU-02 100 µg
Recombinant Human Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1)
Ask
View Details