Neobritannilactone B

Neobritannilactone B, a sesquiterpene, can be isolated from the chloroform fraction of the I. britannica. Neobritannilactone B is cytotoxic. Other extracts of I. britannica are also Dihydrofolate reductase (DHFR) inhibitors, which inhibit Shigella dysenteriae type 1[1][2].

Product Specifications

CAS Number

[886990-00-7]

UNSPSC

12352005

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/neobritannilactone-b.html

Solubility

10 mM in DMSO

Smiles

C=C1C(O[C@H]2/C=C(CC/C=C(C[C@@H]([C@@H]12)O)\C)\C)=O

Molecular Formula

C15H20O3

Molecular Weight

248.32

References & Citations

[1]Choo SJ, et al. Hypo-pigmenting effect of sesquiterpenes from Inula britannica in B16 melanoma cells. Arch Pharm Res. 2014 May;37 (5) :567-74. |[2]Jose S, et al. Phytochemical constituents of Inula britannica as potential inhibitors of dihydrofolate reductase: A strategic approach against shigellosis. J Biomol Struct Dyn. 2022;40 (22) :11932-11947.