NR2B-selective NMDA receptor antagonist 1
Product Specifications
UNSPSC Description
NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC50s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier[1].
Target Antigen
iGluR; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nr2b-selective-nmda-receptor-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
CS(NC1=CC=C(C=C1)OC[C@@H](O)CNCCC2=CC(Cl)=C(C=C2)Cl)(=O)=O
Molecular Weight
433.35
References & Citations
[1]Yesim A Tahirovic, et al. Enantiomeric Propanolamines as selective N-Methyl-D-aspartate 2B Receptor Antagonists. J Med Chem. 2008 Sep 25;51(18):5506-21.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126123/NR2B-selective-NMDA-receptor-antagonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126123/
Clinical Information
No Development Reported
CAS Number
457897-92-6
Curated Selection
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