Numidargistat
Product Specifications
UNSPSC Description
Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].
Target Antigen
Arginase
Type
Reference compound
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CB-1158.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1
Molecular Weight
287.12
References & Citations
[1]Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101.Biomed Pharmacother. 2022 Jun 24;153:113321.|Research Square Preprint. 2022 Mar.|The University of Chicago. 2023 Dec.|bioRxiv. 2023 Sep 10.|Cancer Lett. 2023 May 5;216208.|Cell Commun Signal. 2023 Sep 18;21(1):236.|J Physiol. 2020 Nov;598(21):4907-4925.|Patent. US20240307497A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101979/Numidargistat-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101979/Numidargistat-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2095732-06-0
Available Sizes
Curated Selection
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