Suritozole

Suritozole (MGL-26479) is a cognitive enhancer that acts as a partial inverse agonist of benzodiazepine receptor sites on GABAA ion channel complexes. Suritozole can be used in the study of neurodegenerative diseases[1].

Product Specifications

CAS Number

[110623-33-1]

Product Name Alternative

MDL-26479

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/suritozole.html

Solubility

10 mM in DMSO

Smiles

S=C1N(N=C(N1C)C2=CC=CC(F)=C2)C

Molecular Formula

C10H10FN3S

Molecular Weight

223.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]O'Dell DM, et al. Chronic postinjury administration of MDL 26,479 (Suritozole), a negative modulator at the GABAA receptor, and cognitive impairment in rats following traumatic brain injury. J Neurosurg. 1995 Nov;83 (5) :878-83.