GANT 58

GANT 58 (NSC 75503) is a potent GLI antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM[1].

Product Specifications

CAS Number

[64048-12-0]

Product Name Alternative

NSC 75503

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Gli

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GANT-58.html

Purity

99.37

Solubility

DMSO : 9.09 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic)

Smiles

C1(C2=C(C(C3=CC=NC=C3)=C(S2)C4=CC=NC=C4)C5=CC=NC=C5)=CC=NC=C1

Molecular Formula

C24H16N4S

Molecular Weight

392.48

Precautions

H315, H319, H335

References & Citations

[1]Lauth M, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007 May 15;104 (20) :8455-60.|[2]Joo J, et al. GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One. 2009 Oct 27;4 (10) :e7608.