L-Ascorbic acid (GMP Like)

L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

Product Specifications

CAS Number

[50-81-7]

Product Name Alternative

L-Ascorbate (GMP Like) ; Vitamin C (GMP Like)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Type

GMP Small Molecules

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-ascorbic-acid-gmp-like.html

Purity

99.88

Solubility

H2O : 100 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic)

Smiles

OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O

Molecular Formula

C6H8O6

Molecular Weight

176.12

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27 (46) :12577-83.|[2]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75 (3) :173-82.|[3]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8 (1) :11372.|[4]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5 (1) :2.|[5]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22 (1) :18-35.|[6]Esteban MA, Wang T, Qin B, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell. 2010;6 (1) :71-79. doi:10.1016/j.stem.2009.12.001|[7]Talkhabi M, Pahlavan S, Aghdami N, Baharvand H. Ascorbic acid promotes the direct conversion of mouse fibroblasts into beating cardiomyocytes. Biochem Biophys Res Commun. 2015;463 (4) :699-705. |[8]Stadtfeld M, Apostolou E, Ferrari F, et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012;44 (4) :398-S2.