COB-187
Product Specifications
UNSPSC Description
COB-187 is a potent, ATP-competitive and selective inhibitor of GSK-3β. COB-187 inhibits GSK-3 through a reversible and Cysteine (Cys)-199-dependent mechanism. COB-187 inhibits LPS induced cytokine production and SARS-CoV-2 spike protein-induced CXCL10 production[1].
Target Antigen
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR;Stem Cell/Wnt
Field of Research
Cancer; Infection; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cob-187.html
Smiles
OC1(CSC(N1CC2=CC=NC=C2)=S)C3=CC=CC=C3
Molecular Weight
302.41
References & Citations
[1]Mehrani R, et al. Capturing the Effects of Single Atom Substitutions on the Inhibition Efficiency of Glycogen Synthase Kinase-3β Inhibitors via Markov State Modeling and Experiments. J Chem Theory Comput. 2024 Jul 8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162675/COB-187-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162675/
Clinical Information
No Development Reported
CAS Number
1862177-86-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
17059151 3x1.0μg DNA
CTGLF12P CRISPR All-in-one AAV vector set (with saCas9)(Human)
Ask
View Details 
MBS6150618-01 0.1 mL
ZPLD1 (Zona Pellucida-like Domain-containing Protein 1, ZP Domain-containing Protein 1) (FITC)
Ask
View Details MBS6150618-02 5x 0.1 mL
ZPLD1 (Zona Pellucida-like Domain-containing Protein 1, ZP Domain-containing Protein 1) (FITC)
Ask
View Details 
BNC942990-100 100 µL
Anti-CD63 (Late Endosomes Marker) (LAMP3/2990R), CF594 conjugate
Ask
View Details 