Amiloride
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]) . Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
Product Specifications
CAS Number
[2609-46-3]
Product Name Alternative
MK-870
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Apoptosis; Sodium Channel; TRP Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/amiloride.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N
Molecular Formula
C6H8ClN7O
Molecular Weight
229.63
Precautions
H301, H311, H331
References & Citations
[1]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303 (12) : p. L1013-26.|[2]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20 (1) :109-17.|[3]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29 (7) :1176-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
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