Hydrastine (Standard)
Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927) . This product is intended for research and analytical applications. Hydrastine ((-) -β-Hydrastine; (1R,9S) -β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells) . Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM) . Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage[1][2].
Product Specifications
Product Name Alternative
(-) -β-Hydrastine (Standard) ; (1R,9S) -β-Hydrastine (Standard)
UNSPSC
12352005
Target
Dopamine Receptor; OAT; Reference Standards; Tyrosine Hydroxylase
Type
Reference Standards
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hydrastine-standard.html
Smiles
O=C1O[C@H]([C@@H]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=C1C(OC)=C(OC)C=C5
Molecular Formula
C21H21NO6
Molecular Weight
383.39
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0927R/Hydrastine-Standard-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0927R/
Scientific Category
Reference Standards
CAS Number
[118-08-1]
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