Alinidine

Alinidine (St-567) is a specific bradycardic agent. Alinidine reduces the slope of the diastolic depolarization in sinoatrial tissue and Purkinje fibers. Alinidine shows antiischemic and antiarrhythmic effects[1][2].

Product Specifications

CAS Number

[33178-86-8]

Product Name Alternative

St-567

UNSPSC

12352005

Hazard Statement

H301-H315-H319-H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/alinidine.html

Smiles

ClC1=CC=CC(Cl)=C1N(CC=C)C2=NCCN2

Molecular Formula

C12H13Cl2N3

Molecular Weight

270.16

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Snyders DJ, et al. Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflugers Arch. 1987;410 (1-2) :83-91.|[2]J L Challinor-Rogers, et al. Antiischemic and antiarrhythmic activities of some novel alinidine analogs in the rat heart. J Cardiovasc Pharmacol. 1997 Apr;29 (4) :499-507.