Pindolol
Pindolol (LB-46) is the antagonist for 5-HT 1A (Ki=33 nM) and 5-HT 1B. Pindolol is the antagonist for β1/β2-adrenergic receptor. Pindolol exhibits anti-anxiety and antidepressant effects[1][2].
Product Specifications
CAS Number
[13523-86-9]
Product Name Alternative
LB-46
UNSPSC
12352005
Hazard Statement
H301
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pindolol.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(CNC(C)C)COC1=CC=CC2=C1C=CN2
Molecular Formula
C14H20N2O2
Molecular Weight
248.32
Precautions
H301
References & Citations
[1]Patkar OL, et al., Pindolol Rescues Anxiety-Like Behavior and Neurogenic Maladaptations of Long-Term Binge Alcohol Intake in Mice. Front Behav Neurosci. 2019 Nov 29;13:264.|[2]Fernandes E, et al., Pindolol is a potent scavenger of reactive nitrogen species. Life Sci. 2005 Sep 2;77 (16) :1983-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; mLAG-3
Available Sizes
Curated Selection
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