NAE-IN-1
Product Specifications
UNSPSC Description
NAE-IN-1 (compound X-10) is a potent NAE1 inhibitor. NAE-IN-1 induces apoptosis and cell cycle arrest at the G2/M phase. NAE-IN-1 increases ROS levels and prevents cell migration. NAE-IN-1 shows anti-proliferation activity[1].
Target Antigen
Apoptosis; NEDD8-activating Enzyme; Reactive Oxygen Species
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nae-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(N=C(NC(C2=CC=C(CC)C=C2)=O)S3)C3=C1)C(CC4)CCN4CC5=CC=CC=C5
Molecular Weight
498.64
References & Citations
[1]Wang X, et al. Identification of novel benzothiazole derivatives as inhibitors of NEDDylation pathway to inhibit the progression of gastric cancer. Bioorg Med Chem Lett. 2024 Mar 1;100:129647.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161268/NAE-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161268/
Clinical Information
No Development Reported
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