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(RS) -MCPG

(RS) -MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS) -MCPG blocks theta-burst stimulation (TBS) -induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].

Product Specifications

CAS Number

[146669-29-6]

Product Name Alternative

Alpha-MCPG

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_RS_-MCPG.html

Purity

99.05

Solubility

1M NaOH : 100 mg/mL (ultrasonic; adjust pH to 10 with NaOH) |DMSO : 6 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL (ultrasonic; heat to 80°C)

Smiles

CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1

Molecular Formula

C10H11NO4

Molecular Weight

209.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Yang B et al. Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. PLoS One, 2015 Sep 21, 10 (9) :e0138215.|[2]Fiona Yeuk-Lun Choi, et al. The effects of (RS) -MCPG on amphetamine-induced sensitization in neonatal rats.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR

Available Sizes

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