GSK575594A
Product Specifications
UNSPSC Description
GSK575594A is a modulator of the nicotinic acetylcholine receptor (nAChR) in Ascaris suum. GSK575594A enhances muscle contractions induced by acetylcholine (ACh) by binding to the allosteric binding site between subunits within the transmembrane domain of nAChR. At a concentration of 3 μM, GSK575594A significantly increased the contraction induced by ACh in Ascaris suum (Emax increased from 1.19 g to 1.51 g). GSK575594A may be used in research within the field of antiparasitic studies[1].
Target Antigen
nAChR; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gsk575594a.html
Smiles
O=C(N1CCN(C2=CC=C(N)C=C2F)CC1)C3=CC(S(=O)(C)=O)=CC=C3C4=CC=C(F)C=C4
Molecular Weight
471.52
References & Citations
[1]Stevanovic S, et al. Potential modulating effect of the Ascaris suum nicotinic acetylcholine receptor (nAChR) by compounds GSK575594A, diazepam and flumazenil discovered by structure-based virtual screening approach. Mol Biochem Parasitol. 2021 Mar;242:111350.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111161/GSK575594A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111161/
Clinical Information
No Development Reported
CAS Number
909418-68-4
Curated Selection
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