PGR Antibody / Progesterone Receptor

This MAb is specific to PR/PGR and shows minimal cross-reaction with other members of the family. PR is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa) . Expression of PgR has been suggested to reflect an intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone. It is excellent for immunohistochemical staining of formalin/paraffin tissues.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P06401

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 483-571 was used as the immunogen for the PGR antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

PGR/3817

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Aliquot the PGR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This PGR antibody is available for research use only.

Storage Conditions

Aliquot the PGR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the PGR antibody should be determined by the researcher.

Location

Nucleus

Image Legend

IHC staining of FFPE human breast carcinoma tissue with PGR antibody (clone PGR/3817) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.