Thyroid transcription factor 1 Antibody / TTF-1 / NX2.1
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1) . TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P43699
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment (within amino acids 1-200) of human TTF-1 protein was used as the immunogen for the Thyroid transcription factor 1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
NX2.1/9036
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the Thyroid transcription factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Thyroid transcription factor 1 antibody is available for research use only.
Storage Conditions
Aliquot the Thyroid transcription factor 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.nsjbio.com/tds-pdf/thyroid-transcription-factor-1-antibody-ttf-1-nx21-nx219036-v5552
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Thyroid transcription factor 1 antibody should be determined by the researcher.
CAS Number
9007-83-4
Location
Nucleus
Image Legend
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