EphB3 Antibody / Ephrin Receptor B3

Ephrin Receptor EphB3, is also known as human embryo kinase 2 (HEK2) or Eph-like tyrosine kinase 2 (ETK2). EPHB3, which is a member of the EPH/ELK family of tyrosine kinases, encodes a 998-amino acid polypeptide having a single putative transmembrane domain, a secretory signal sequence, and 2 fibronectin repeats. The EPHB3 gene is mapped to human chromosome 3q21-qter. EPHB3/HEK2 interacts with 2 ligands of EPH-related kinases (LERKs), namely, LERK2 (EFNB1) and LERK5 (EFNB2). Coincubation of HEK2- and LERK2-expressing cells induces cell-cell adhesion and aggregation. Additionally, coexpression of EPHB3/HEK2 and LERK2 results in reduced kinase activity of EPHB3/HEK2.