Tocainide
Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2].
Product Specifications
CAS Number
[41708-72-9]
UNSPSC
12352005
Hazard Statement
H302
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tocainide.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(N)C(NC1=C(C)C=CC=C1C)=O
Molecular Formula
C11H16N2O
Molecular Weight
192.26
Precautions
H302
References & Citations
[1]Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3 (6) :316-23.|[2]De Luca A, et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64 (4) :932-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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