Hypothemycin

Hypothemycin, a fungal polyketide, is a multikinase inhibitor with Kis of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively[1][2].

Product Specifications

CAS Number

[76958-67-3]

UNSPSC

12352005

Hazard Statement

H302

Target

ERK; FLT3; MEK; PDGFR; VEGFR

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hypothemycin.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC(O)=C(C(O[C@@H](C)C/C=C\C2=O)=O)C([C@@H](O3)[C@@]3([H])C[C@H](O)[C@@H]2O)=C1

Molecular Formula

C19H22O8

Molecular Weight

378.37

Precautions

H302

References & Citations

[1]Schirmer A, et al. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Proc Natl Acad Sci U S A. 2006 Mar 14;103 (11) :4234-9.|[2]Nishino M, et al. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei. Elife. 2013 Jul 9;2:e00712.