MMP-23 (V371) polyclonal antibody
Product Specifications
Background
Matrix metalloproteinases (MMPs) are highly homologous Zn2+ endopeptidases involved in extracellular matrix breakdown. MMP mediated extracellular remodeling occurs in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, including arthritis and metastasis. MMP-23 exhibits sequence similarity with most MMPs, but displays a difference in domain structure. The MMP-23 protein contains prepro-, catalytic, cysteine-rich, Interleukin-1 receptor-related and proline-rich domains. Lacking a recognizable signal sequence, MMP-23 has a short prodomain. In addition, MMP-23 contains a single cysteine residue that can be part of the cysteine-switch mechanism operation for maintaining enzyme latency. MMP-23 is a membrane-anchored glycoprotein with type II topology. Subcellular localization is predominantly perinuclear.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Matrix metalloproteinase-23; MMP 23; Femalysin; MIFR-1; Matrix metalloproteinase-21; MMP-21; Matrix metalloproteinase-22; MMP-22; Matrix metalloproteinase-23, soluble form; MMP23A; MMP21; MMP23B; MMP21; MMP22; MMP23
Swiss Prot
O75900
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 341-390 of Human MMP-23.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 44 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
MMP-23 (V371) polyclonal antibody detects endogenous levels of MMP-23 protein.
Applications Notes
Western blot (WB) analysis of MMP-23 (V371) polyclonal antibody at 1:500 dilution Lane1:BV2 whole cell lysate (40ug) Lane2:H9C2 whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug) Lane4:SK-OVCAR3 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Curated Selection
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