AGBL4 polyclonal antibody

Product Specifications

Background

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Cytosolic carboxypeptidase 6; ATP/GTP-binding protein-like 4; AGBL4; CCP6

Swiss Prot

Q5VU57

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to Human AGBL4.

Conjugation

Unconjugated

Applications

Dilution

WB:1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 72 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

AGBL4 polyclonal antibody detects endogenous levels of AGBL4 protein.

Applications Notes

Western blot (WB) analysis of AGBL4 polyclonal antibody at 1:500 dilution LaneA:CT26 whole cell lysate LaneB:PC12 whole cell lysate LaneC:Hela whole cell lysate LaneD:COS-7 whole cell lysate LaneE:PC3 whole cell lysate