AR polyclonal antibody
Product Specifications
Background
Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding. This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; AR; DHTR; NR3C4
Swiss Prot
P10275
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to Human AR.
Conjugation
Unconjugated
Applications
WB IF IHC
Dilution
WB: 1:2000~1:5000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 140 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
AR polyclonal antibody detects endogenous levels of AR protein.
Applications Notes
Western blot (WB) analysis of AR polyclonal antibody at 1:2000 dilution Lane1:CT-26 whole cell lysate (40ug) Lane2:PC3 whole cell lysate (40ug) Lane3:HepG2 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Curated Selection
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