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HLA-G monoclonal antibody

Product Specifications

Background

HLA-G is a non-classical MHC molecule expressed by trophoblasts in placenta, thymic epithelial cells, and some tumors.Alternative splicing leads to generation of at least six isoforms, four that are transmembrane proteins and two that are soluble. It is an inhibitory molecule involved in immune tolerance and escape, originally studied for its role in maternal tolerance of the fetus during pregnancy. HLA-G binds ILT2, ILT4, and KIR2DL4, playing a role in the regulation of natural killer, T, and monocyte/macrophage cells . Its involvement in evasion of immune response makes it a potential target for immunotherapy.

Structure Composition

Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

HLA-6.0; HLAG; HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; MHC class I antigen G

Swiss Prot

P17693

Reactivity

Human

Immunogen

Recombinant fusion protein of human HLA-G. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB

Dilution

WB (1/500 - 1/1000)

Purity

This antibody is purified through a protein G column.

Modification

Unmodification

Molecular Weight

~ 43 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of HLA-G protein.

Applications Notes

Western blot analysis of HLA-G expression in A549 (A), Ramos (B), MDAMB231 (C) whole cell lysates.

Host or Source

Mouse

CAS Number

9007-83-4

Available Sizes

Curated Selection

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