Histone H2B (AcK116) polyclonal antibody

Product Specifications

Background

Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones ore component of nucleosome .Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability .DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling .Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear.

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

HIST1H2BA; TSH2B; Histone H2B type 1-A; Histone H2B testis; Testis-specific histone H2B; HIST1H2BB; H2BFF; Histone H2B type 1-B; Histone H2B.1; Histone H2B.f; H2B/f; HIST1H2BC; H2BFL; HIST1H2BE; H2BFH; HIST1H2BF; H2BFG; HIST1H2BG; H2BFA; HIST1H2BI; H2BFK; Histone H2B type 1-C/E/F/G/I; Histone H2B.1 A; Histone H2B.a; H2B/a; Histone H2B.g; H2B/g; Histone H2B.h; H2B/h; Histone H2B.k; H2B/k; Histone H2B.l; H2B/l

Swiss Prot

Q96A08; P33778; P62807

Reactivity

Human, Zebrafish

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Histone H2B with an acetylation site at K116. The exact sequence is proprietary.