Kobophenol A

Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 µM[1][2].

Product Specifications

CAS Number

[124027-58-3]

UNSPSC

12352005

Target

PKC; SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/kobophenol-a.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC([C@H]([C@@H](C(C=C2)=CC=C2O)OC3=C4)C3=C([C@@H]5[C@H](C6=CC(O)=CC(O)=C6)[C@@H](C(C=C7)=CC=C7O)O[C@@H]5C(C=C8)=CC=C8O)C=C4O)=C9[C@@H](C%10=CC(O)=CC(O)=C%10)[C@H](C(C=C%11)=CC=C%11O)OC9=C1

Molecular Formula

C56H44O13

Molecular Weight

924.94

References & Citations

[1]Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12 (7) :1793-1802.|[2]Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29 (11) :818-822.