NRMA-8

NRMA-8 is a brain-penetrant small molecule nuclear receptor modulator. NRMA-8 is promising for research of central nervous system disorders, including Alzheimer's disease, Parkinson's disease, demylenation disorders and glioblastomas[1][2].

Product Specifications

CAS Number

[2375659-15-5]

UNSPSC

12352005

Target

FAAH

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nrma-8.html

Smiles

O=C(C1=CC=C(C=C1)Cl)NCCC2=CC=C(C=C2)OC(C)(C)C(NC)=O

Molecular Formula

C20H23ClN2O3

Molecular Weight

374.86

References & Citations

[1]SCANLAN Thomas S, et al. N-methyl amide prodrugs of small molecule nuclear receptor modulators. WO2019168842. 2018 March 02.|[2]Ferrara SJ, et al. A CNS-Targeting Prodrug Strategy for Nuclear Receptor Modulators. J Med Chem. 2020 Sep 10;63 (17) :9742-9751.