Mangafodipir

Mangafodipir, hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir shows no negative interference with the tumoricidal activity of chemotherapy[1][2].

Product Specifications

CAS Number

[155319-91-8]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mangafodipir.html

Solubility

10 mM in DMSO

Smiles

O=C1[O-][Mn+2]([N]2(C3)CC4=C5COP([O-])([O-])=O)([O-]C6=C(N=C7)C)([O-]C4=C(N=C5)C)([O-]C3=O)[N](CC6=C7COP([O-])([O-])=O)(CC2)C1.[H+].[H+].[H+].[H+].[H+].[H+]

Molecular Formula

C22H30MnN4O14P2

Molecular Weight

691.38

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Karlsson JOG, et al. Mangafodipir a Selective Cytoprotectant - with Special Reference to Oxaliplatin and Its Association to Chemotherapy-Induced Peripheral Neuropathy (CIPN) . Transl Oncol. 2017 Aug;10 (4) :641-649. |[2]Wang C. Mangafodipir trisodium (MnDPDP) -enhanced magnetic resonance imaging of the liver and pancreas. Acta Radiol Suppl. 1998;415:1-31.