Protriptyline

Protriptyline is a potent tricyclic antidepressant (TCA) . Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease[1][2][3].

Product Specifications

CAS Number

[438-60-8]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Amyloid-β; Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/protriptyline.html

Solubility

10 mM in DMSO

Smiles

CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13

Molecular Formula

C19H21N

Molecular Weight

263.38

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9 (8) :e105196.|[2]Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35 (5) :429-34.|[3]Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261.