Fluticasone

Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells[1][2].

Product Specifications

CAS Number

[90566-53-3]

UNSPSC

12352100

Hazard Statement

H315, H319, H320

Target

Glucocorticoid Receptor; Smo

Type

Reference compound

Related Pathways

Immunology/Inflammation; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fluticasone.html

Concentration

10mM

Purity

98.70

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@]([C@](O)1C(SCF)=O)(C[C@@H]2O)[C@](C[C@H]1C)([H])[C@@](C[C@@H]3F)([H])[C@]2([C@](C3=CC4=O)(C=C4)C)F

Molecular Formula

C22H27F3O4S

Molecular Weight

444.51

Precautions

H315, H319, H320

References & Citations

[1]Seidel P, et al. Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies. Respir Res. 2012 Oct 4. 13 (1) :90.|[2]Wang J, et al. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010 May 18. 107 (20) :9323-8. |[3]Ying Wang, et al. Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Front. Cell. Infect. Microbiol., 2020 Jun. |[4]Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26. 385 (Suppl 1) :S88.